LAZARUS/OISHI Laboratory

Chen ZK, Dong H, Liu CW, Liu WY, Zhao YN, Xu W, Sun X, Xiong YY, Liu YY, Yuan XS, Wang B, Lazarus M, Chérasse Y, Li YD, Han F, Qu WM, Ding FF, Huang ZL. A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy. Cell Discov. 8:115, doi: 10.1038/s41421-022-00456-5. 2023

Takahashi A, Durand-de Cuttoli R, Flanigan ME, Hasegawa E, Tsunematsu T, Aleyasin H, Cherasse Y, Miya K, Okada T, Keino-Masu K, Mitsui K, Li L, Patel V, Blitzer RD, Lazarus M, Tanaka KF, Yamanaka A, Sakurai T, Ogawa S, Russo SJ. Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice. Nat Commun. 13:4039, doi: 10.1038/s41467-022-31728-z. 2023

Li YD, Luo YJ, Chen ZK, Quintanilla L, Cherasse Y, Zhang L, Lazarus M, Huang ZL, Song J. Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior. Nat Neurosci. 25(5):630-645. doi: 10.1038/s41593-022-01065-x. 2022

Tao X, Zhang R, Du R, Yu T, Yang H, Li J, Wang Y, Liu Q, Zuo S, Wang X, Lazarus M, Zhou L, Wang B, Yu Y, Shen Y. EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis model. J Exp Med. 219(5):e20212414. doi: 10.1084/jem.20212414. 2022

Tsai CJ, Nagata T, Liu CY, Suganuma T, Kanda T, Miyazaki T, Liu K, Saitoh T, Nagase H, Lazarus M, Vogt KE, Yanagisawa M, Hayashi Y. Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors. Cell Rep. 36(7):109558. doi: 10.1016/j.celrep.2021.109558. 2021

Yang YF, Dong H, Shen Y, Li L, Lazarus M, Qu WM, Huang ZL. Mesencephalic dopamine neurons are essential for modafinil-induced arousal. Br J Pharmacol. 178(24):4808-4825. doi: 10.1111/bph.15660. 2021

Li Y, Luo Y, Xu W, Ge J, Cherasse Y, Wang Y, Lazarus M, Qu W, Huang Z. Ventral pallidal GABAergic neurons control wakefulness associated with motivation through the ventral tegmental pathway, Molecular Psychiatry, 26(7):2912-2928, doi:10.1038/s41380-020-00906-0, 2021

Xu Q, Wang DR, Dong H, Chen L, Lu J, Lazarus M, Cherasse Y, Chen GH, Qu WM, Huang ZL. Medial Parabrachial Nucleus Is Essential in Controlling Wakefulness in Rats. Front Neurosci. 15:645877. doi: 10.3389/fnins.2021.645877. 2021

Ji D, Bai P, Zhu Q, Wang N, He Y, Chen G, Lazarus M, Urade Y, Wang J, Wang C, Lu A, Shen Y, Yu Y. Niacin attenuates hypoxia-induced pulmonary arterial hypertension in mice through hematopoietic prostaglandin D synthase in macrophages, Circulation Research, 127(10):1323-1336. doi: 10.1161/CIRCRESAHA.120.316784. 2020

Honda T, Takata Y, Cherasse Y, Mizuno S, Sugiyama F, Takahashi S, Funato H, Yanagisawa M, Lazarus M*, Oishi Y*. Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine D2R-mediated Sleep Reduction. iScience, 23:101240, doi: 10.1016/j.isci.2020.101240. 2020

Li Y, Bao H, Luo Y, Cherasse Y, Sullivan HA, Quintanilla L, Wickersham I, Lazarus M, Shin YI, Song J. Supramammillary nucleus synchronizes with dentate gyrus to regulate spatial memory retrieval through glutamate release. eLife, 9:e53129, doi: 10.7554/eLife.53129, 2020.

Tsai CJ, Liu CY, Lazarus M, Hayashi Y. Sleep architecture of adenosine A2A receptor-deficient mice. Sleep and Biological Rhythms, doi: 10.1007/s41105-020-00260-2, 2020.

Kong D, Wan Q, Li J, Zuo S, Liu G, Liu Q, Wang C, Bai P, Duan SZ, Zhou B, Gounari F, Lu A, Lazarus M, Breyer RM, Yu Y. DP1 Activation Reverses Age Related Hypertension via NEDD4L-Mediated T-bet Degradation in T Cells. Circulation, 141:655–666, doi: 10.1161/CIRCULATIONAHA.119.042532, 2020.

Schütz B, Ruppert AL, Strobel O, Lazarus M, Urade Y, Büchler MW, Weihe E. Distribution pattern and molecular signature of cholinergic tuft cells in human gastro-intestinal and pancreatic-biliary tract. Scientific Reports, 9:17466, doi:10.1038/s41598-019-53997-3, 2019.

Li Y, Ge JG, Luo Y, Wei X, Wang J, Lazarus M, Hong Z, Qu W, Huang Z. High cortical delta power correlates with aggravated allodynia by activating anterior cingulate cortex GABAergic neurons in neuropathic pain mice. Pain, 161:288-299, doi: 10.1097/j.pain.0000000000001725, 2020.

Li R, Wang YQ, Liu WY, Zhang MQ, Li L, Cherasse Y, Schiffmann SN, de Kerchove d’Exaerde A, Lazarus M, Qu WM, Huang ZL. Activation of adenosine A2A receptors in the olfactory tubercle promotes sleep in rodents. Neuropharmacology, doi:10.1016/j.neuropharm.2019.107923, 2019

Fujii S, Kaushik MK, Zhou X, Korkutata M, Lazarus M*. Acute Social Defeat Stress Increases Sleep in Mice. Frontiers in Neuroscience, 13:322, doi: 10.3389/fnins.2019.00322, 2019.

Fujimori K, Aritake K, Oishi Y, Nagata N, Maehara T, Lazarus M, Urade Y. L-PGDS-produced PGD2 in premature, but not in mature, adipocytes increases obesity and insulin resistance. Scientific Reports, 9:1931, doi: 10.1038/s41598-018-38453-y, 2019

Zhang Z, Liu WY, Diao YP, Xu W, Zhong YH, Zhang JY, Lazarus M, Liu YY, Qu WM*, and Huang ZL*. Superior colliculus GABAergic neurons are essential for acute dark-induction of wakefulness in mice. Current Biology, 29:637-644, doi: 10.1016/j.cub.2018.12.031, 2019

Zhou X, Oishi Y, Cherasse Y, Korkutata M, Fujii S, Lee CY, Lazarus M. Extracellular adenosine and slow-wave sleep are increased after ablation of nucleus accumbens core astrocytes and neurons in mice. Neurochemistry International, 124:256-263, doi: 10.1016/j.neuint.2019.01.020, 2019

Korkutata M, Saitoh T, Cherasse Y, Ioka S, Duo F, Qin R, Murakoshi N, Fujii S, Zhou X, Sugiyama F, Chen JF, Kumagai H, Nagase H, Lazarus M*. Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function. Neuropharmacology, 144:122-132, doi: 10.1016/j.neuropharm.2018.10.022, 2019.

Takata Y, Oishi Y, Zhou XZ, Hasegawa E, Takahashi K, Cherasse Y, Sakurai T, Lazarus M*. Sleep and wakefulness are controlled by ventral medial midbrain/pons GABAergic neurons in mice. Journal of Neuroscience, doi: 10.1523/JNEUROSCI.0598-18.2018, 2018.

Anaclet C, De Luca R, Venner A, Malyshevskaya O, Lazarus M, Arrigoni E, Fuller PM. Genetic activation, inactivation and deletion reveal a limited and nuanced role for somatostatin-containing basal forebrain neurons in behavioral state control. Journal of Neuroscience, doi: 10.1523/JNEUROSCI.2955-17.2018, 2018.

Yang SR, Hu ZZ, Luo YJ, Zhao YN, Sun HX, Yin D, Wang CY, Yan YD, Wang DR, Yuan XS, Ye CB, Guo W, Qu WM, Cherasse Y, Lazarus M, Ding YQ, Huang ZL. 2018. The rostromedial tegmental nucleus is essential for non-rapid eye movement sleep. PLoS Biology, 16(4):e2002909, doi: 10.1371/journal.pbio.2002909, 2018.

Luo YJ, Li YD, Wang L, Yang SR, Yuan XS, Wang J, Cherasse Y, Lazarus M, Chen JF, Qu WM, Huang ZL. 2018. Nucleus accumbens controls wakefulness by a subpopulation of neurons expressing dopamine D1 receptors. Nature Communications, 9:1576, doi:10.1038/s41467-018-03889-3, 2018.

Valencia Garcia S, Brischoux F, Clement F, Libourel PA, Arthaud S, Lazarus M, Luppi PH, Fort P. Genetic inactivation of ventromedial medulla inhibitory neurons induces REM sleep without atonia and REM sleep behavior disorder. Nature Communications, 9: article 505, doi: 10.1038/s41467-017-02761-0, 2018.

Kaur S, Wang JL, Ferrari L, Thankachan S, Kroeger D, Venner A, Lazarus M, Wellman A, Arrigoni E, Fuller PM, Saper CB. A Genetically defined circuit for arousal from sleep during hypercapnia. Neuron, 96:1153-1167, doi: 10.1016/j.neuron.2017.10.009, 2017.

Yuan XS, Wang L, Dong H, Qu WM, Yang SR, Cherasse Y, Lazarus M, Schiffmann SN, d’Exaerde AK, Li RX, Huang ZL. Striatal adenosine A(2A) receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus. eLife, 6:e29055, doi: 10.7554/eLife.29055, 2017.

Liu J, Zhang MQ, Wu X, Lazarus M, Cherasse Y, Yuan MY, Huang ZL, Li RX. Activation of Parvalbumin Neurons in the Rostro-Dorsal Sector of the Thalamic Reticular Nucleus Promotes Sensitivity to Pain in Mice. Neuroscience, doi: 10.1016/j.neuroscience.2017.10.013, 2017.

Shinohara R, Taniguchi M, Ehrlich AT, Yokogawa K, Deguchi Y, Cherasse Y, Lazarus M, Urade Y, Ogawa A, Kitaoka S, Sawa A, Narumiya S, Furuyashiki T. Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice. Molecular Psychiatry, doi: 10.1038/mp.2017.177, 2017.

Oishi Y, Xu Q, Wang L, Zhang BJ, Takahashi K, Takata Y, Luo YJ, Cherasse Y, Schiffmann SN, de Kerchove d’Exaerde A, Urade Y, Qu WM, Huang ZL, LazarusM. Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice. Nature Communications, 8: article 734, doi: 10.1038/s41467-017-00781-4, 2017.

Li J, Kong D, Wang Q, Wu W, Tang Y, Bai T, Guo L, Wei L, Zhang Q, Yu Y, Qian Y, Zuo S, Liu G, Liu Q, Wu S, Zang Y, Wang Y, Yao W, Ji Y, Nakamura M, Lazarus M, Breyer RM, Wang L, Yu Y. Niacin ameliorates ulcerative colitis by activation of D prostanoid receptor 1. EMBO Molecular Medicine, 9:571-588, doi: 10.15252/emmm.201606987, 2017

Tang J, Shen Y, Chen G, Wan Q, Wang K, Zhang J, Qin J, Liu G, Zuo S, Tao B, Yu Y, Wang J, Lazarus M, Yu Y. Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction. Nature Communications, 14656, doi: 10.1038/ncomms14656, 2017.

Oishi Y, Suzuki Y, Takahashi K, Yonezawa T, Kanda T, Takata Y, Cherasse Y, Lazarus M. Activation of ventral tegmental area dopamine neurons produces wakefulness through dopamine D2–like receptors in mice. Brain Structure & Function, doi: 10.1007/s00429-017-1365-7

Kong D, Li JJ, Shen YJ, Liu GH, Zuo SG, Tao B, Ji Y, Lu AK, Lazarus M, Breyer RM, Yu Y. Niacin promotes cardiac healing after myocardial infarction through activation of the myeloid prostaglandin D2 receptor subtype 1. Journal of Pharmacology and Experimental Therapeutics, doi: 10.1124/jpet.116.238261, 2017.

Zhang BJ, Shao SR, Aritake K, Takeuchi A, Urade Y, Huang ZL, Lazarus M*, Qu WM. Interleukin-1b induces sleep independent of prostaglandin D2 in rats and mice. Neuroscience, 340:258-267, doi: 10.1016/j.neuroscience.2016.09.053, 2017. *Corresponding author

McEown K, Takata Y, Cherasse Y, Nagata N, Aritake K, Lazarus M. Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption. eLife, 5:e20269, 2016. Featured in ScienceDaily, Yahoo! Japan News (279 comments), Asahi Newspaper and NHK News.

Deguchi Y, Harada M, Shinohara R, Lazarus M, Cherasse Y, Urade Y, Yamada D,Sekiguchi M, Watanabe D, Furuyashiki T, Narumiya S. mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety. Cell Reports, 17:2405-2417, doi: 10.1016/j.celrep.2016.10.088, 2016.

Valencia Garcia S, Libourel PA, Lazarus M, Grassi D, Luppi PH, Fort P. Genetic inactivation of glutamate neurons in the rat sublaterodorsal tegmental nucleus recapitulates REM sleep behaviour disorder. Brain, 140: 414-428, doi: 10.1093/brain/aww310, 2016.

Kong D, Shen Y, Liu G, Zuo S, Ji Y, Lu A, Nakamura M, Lazarus M, Stratakis CA, Breyer RM, Yu Y. PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation. Journal of Experimental Medicine, 213: 2209-26, doi: 10.1084/jem.20160459, 2016.

Wang YQ, Li R, Wang DR, Cherasse Y, Zhang Z, Zhang MQ, Lavielle O, McEown K, Schiffmann SN, de Kerchove d’Exaerde A, Qu WM, Lazarus M*, Huang ZL. Brain Structure & Function, doi: 10.1007/s00429-016-1281-2, 2016.

Chen L, Yin D, Wang TX, Guo W, Dong H, Xu Q, Luo YJ, Cherasse Y, Lazarus M, Qiu ZL, Lu J, Qu WM, and Huang ZL. Basal forebrain cholinergic neurons primarily contribute to inhibition of electroencephalogram delta activity, rather than inducing behavioral wakefulness in mice. Neuropsychopharmacology, 41:2133-2146, doi: 10.1038/npp.2016.13, 2016.

Fujinaka A, Li R, Hayashi M, Kumar D, Changarathil G, Naito K, Miki K, Nishiyama T, Lazarus M, Sakurai T, Kee N, Nakajima S, Wang SH, Sakaguchi M. Effect of context exposure after fear learning on memory generalization in mice. Molecular Brain, 9:2. doi: 10.1186/s13041-015-0184-0, 2016.

Fritz M, Klawonn AM, Nilsson A, Zajdel J, Wilhelm DB, Lazarus M, Löfberg A, Jaarola M, Kugelberg UÖ, Billiar TR, Hackam DJ, Sodhi CP, Breyer MD, Jakobsson J, Schwaninger M, Schütz G, Parkitna JR, Saper CB, Blomqvist A, Engblom D. Inflammation‐induced aversion is elicited by prostaglandin mediated modulation of motivational circuitry. Journal of Clinical Investigation, 126:695-705, 2016.

Oishi Y, Takata Y, Taguchi Y, Kohtoh S, Urade Y, Lazarus M. Polygraphic Recording Procedure for Measuring Sleep in Mice. Journal of Visualized Experiments, 25:e53678, doi:10.3791/53678, 2016.

 Cherasse Y, Saito H, Nagata N, Aritake K, Lazarus M, Urade Y. Zinc-containing yeast extract promotes nonrapid eye movement sleep in mice. Molecular Nutrition & Food Research, 59:2087–2093, 2015.

Lopez-Huerta VG, Nakano Y, Bausenwein J, Jaidar O, Lazarus M, Cherassse Y, Garcia-Munoz M, Arbuthnott G. The neostriatum: Two entities, one structure? Brain Structure & Function, 221:1737, 2016

Lu A, Zuo C, He Y, Chen G, Piao L, Zhang J, Xiao B, Shen Y, Tang J, Kong D, Alberti S, Chen D, Zuo S, Zhang Q, Yan S, Yuan F, Zhou B, Duan SZ, Yu Y, Lazarus M, Su Y, Breyer R, Funk C, Yu Y. EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-β1 signaling. Journal of Clinical Investigation, 125:1228-42, doi:10.1172/JCI77656, 2015.

Oishi Y, Yoshida K, Scammell TE, Urade Y, Lazarus M*, Saper CB. The roles of prostaglandin E2 and D2 in lipopolysaccharide-mediated changes in sleep. Brain Behavior and Immunity, 47:172-177, doi: 10.1016/j.bbi.2014.11.019, 2015.

Yazaki-Sugiyama Y, Yanagihara S, Fuller PM, Lazarus M. Acute inhibition of a cortical motor area impairs vocal control in singing zebra finches. European Journal of Neuroscience, 41:97-108, doi: 10.1111/ejn.12757, 2015.

Inutsuka A, Inui A, Tabuchi S, Tsunematsu T, Lazarus M, Yamanaka A. Concurrent and robust regulation of feeding behaviors and metabolism by orexin neurons. Neuropharmacology, 85:451-460, doi: 10.1016/j.neuropharm.2014.06.015, 2014.

Mogk S, Meiwes A, Shtopel S, Schraermeyer U, Lazarus M, Kubata B, Wolburg H, Duszenko M. Cyclical Appearance of African Trypanosomes in the Cerebrospinal Fluid: New Insights in How Trypanosomes Enter the CNS. PLoS ONE 2014; 9:e91372.

Kaneko K, Mizushige T, Miyazaki Y, Lazarus M, Urade Y, Yoshikawa M,Kanamoto R, Ohinata K. δ Opioid receptor activation stimulates normal diet intake but conversely suppresses high-fat diet intake in mice. Am J Physiol Regul Integr Comp Physiol. 2014; doi: 10.1152/ajpregu.00405.2013.

Kaushik MK, Aritake K, Kamauchi S, Hayaishi O, Huang ZL, Lazarus M*, Urade Y*. Prostaglandin D2 is crucial for seizure suppression and postictal sleep. Exp Neurol. 2014; 253: 82-90; doi: 10.1016/j.expneurol.2013.12.002. Commentary by Mello CF, Oliveira MS. Prostaglandin D2 is crucial for seizure suppression and postictal sleep. Novel evidence supporting a role for prostanoid receptors in seizure control. Exp Neurol. 2014; 257: 157-161. 

Xu Q, Xu XH, Qu WM, Lazarus M, Urade Y, Huang ZL. A mouse model mimicking human first night effect for the evaluation of hypnotics. Pharmacol Biochem Behav. 2014; doi: 10.1016/j.pbb.2013.11.029.

Zhang J, Xu Q, Yuan X, Cherasse Y, Schiffmann SN, De Kerchove D’Exaerde A, Qu W, Urade Y, Lazarus M*, Huang ZL*, Li R*. Projections of nucleus accumbens adenosine A2A receptor neurons in the mouse brain and their implications in mediating sleep-wake regulation. Front Neuroanat. 2013; doi: 10.3389/fnana.2013.00043. 

Zhang J, Zou F, Tang J, Zhang Q, Gong Y, Wang Q, Shen Y, Xiong L, Breyer RM, Lazarus M, Funk CD, Yu Y. COX-2-Derived PGE2 Promotes Injury-Induced Vascular Neointimal HyperplasiaThrough the EP3 Receptor. Circ Res. 2013; doi: 10.1161/ CIRCRESAHA.113.301033.

Kaur S, Pedersen NP, Yokota S, Hur EE, Fuller PM, Lazarus M, Chamberlin NL, Saper CB. Glutamatergic Signaling from the Parabrachial Nucleus Plays a Critical Role in Hypercapnic Arousal. J. Neurosci. 2013; 10.1523/JNEUROSCI.0173-13.2013.

Kaneko K, Lazarus M, Miyamoto C, Oishi Y, Nagata N, Yang S, Yoshikawa M, Aritake K, Furuyashiki T, Narumiya S, Urade Y, Ohinata K. Orally Administered Rubiscolin-6, a δ Opioid Peptide Derived from Rubisco, Stimulates Food Intake via Leptomeningeal Lipocallin-type Prostaglandin D Synthase in Mice. Mol. Nutr. Food Res. 2012; doi: 10.1002/mnfr.201200155

Oda A, Kentaro K, Mizushige T, Lazarus M, Urade Y, Ohinata K.Characterization of Ovolin, an Orally Active Tryptic Peptide Released from Ovalbumin with Anxiolytic-like Activity. J. Neurochem. 2012; doi: 10.1111/j.1471-4159.2012.07777.x

Wolburg H, Mogk S, Acker S, Frey C, Meinert M, Schönfeld C, Lazarus M,Urade Y, Kubata BK, Duszenko M. Late Stage Infection in Sleeping Sickness. PLoS ONE 2012; 7(3): e34304. doi:10.1371/journal.pone.0034304

Lazarus M, Shen HY, Cherasse Y, Qu WM, Huang ZL, Bass C, Winsky-Sommerer R, Semba K, Fredholm B, Boison D, Hayaishi O, Urade Y, Chen JF. Arousal Effect of Caffeine Depends on Adenosine A2A Receptors in the Shell of the Nucleus Accumbens. J Neurosci 2011; 31: 10067-10075

Gautron L,  Lazarus M (Co-first author), Scott MM, Saper CB, Elmquist JK. Identifying the Efferent Projections of Leptin-Responsive Neurons in the Dorsomedial Hypothalamus Using a Novel Conditional Tracing Approach. J Comp Neurol 2010; 518: 2090–2108.  

Yoshida K, Li X, Cano G, Lazarus M, Saper CB. Parallel Preoptic Pathways for the Inhibition of Hyperthermia. J Neurosci 2009; 29: 11954 –11964

Vardeh D, Wang D, Costigan M, Lazarus M, Saper CB, Woolf CJ,  FitzGerald GA, Samad TA. COX-2 Expressed in Central Neural Cells Mediates Mechanical Inflammatory Pain Hypersensitivity. J Clin Invest2009; 119: 287–294

Lazarus M, Yoshida K, Coppari R, Bass CE, Mochizuki T, Lowell BB, Saper CB. EP3 Prostaglandin Receptors in the Median Preoptic Nucleus Are Critical for Fever Responses. Nat Neurosci 2007; 10: 1131-1133. 

Kilunga KB, Inoue T, Okano Y, Kabututu Z, Martin SK, Lazarus M, Duszenko M, Sumii Y, Kusakari Y, Matsumura H, Kai Y, Sugiyama S, Inaka K, Inui T, Urade Y. Structural and Mutational Analysis of Trypanosoma brucei prostaglandin H2 Reductase provides Insight into the Catalytic Mechanism of Aldo-Ketoreductases. J Biol Chem 2005; 280: 26371-82

Lazarus M, Eguchi N, Matsumoto S, Nagata N, Yano T, Killian GJ, Urade Y. Species-specific Expression of Microsomal PGE Synthase-1 and Cyclooxygenases in Monkey Male Reproductive Organs. Prostaglandins Leukot Essent Fatty Acids 2004; 71: 233-240

Kabututu Z, Martin SK, Nozaki T, Kawazu S, Okada T, Munday CJ, Duszenko M, Lazarus M, Thuita LW, Urade Y, Kubata BK. Prostaglandin Production from Arachidonic Acid and Evidence for a 9,11-Endoperoxide Prostaglandin H2 Reductase in Leishmania. Int J Parasitol 2003; 33: 221-8

Kubata BK, Kabututu Z, Nozaki T, Munday CJ, Fukuzumi S, Ohkubo K, Lazarus M, Maruyama T, Martin SK, Duszenko M, Urade Y. A Key Role for Old Yellow Enzyme in the Metabolism of Drugs by Trypanosoma cruzi. J Exp Med 2002; 196: 1241-51

Lazarus M, Munday CJ, Eguchi N, Matsumoto S, Killian GJ, Kubata BK, Urade Y. Immunohistochemical Localization of Microsomal PGE Synthase-1 and Cyclooxygenases in Male Mouse Reproductive Organs. Endocrinology. 2002; 143: 2410-9

Lazarus M, Kubata BK, Eguchi N, Fujitani Y, Urade Y, Hayaishi O. Biochemical Characterization of Mouse Microsomal Prostaglandin E Synthase-1 and its Colocalization with Cyclooxygenase-2 in Peritoneal Macrophages. Arch Biochem Biophys 2002; 397: 336-41

Mizoguchi A, Eguchi N, Kimura K, Kiyohara Y, Qu WM, Huang ZL, Mochizuki T, Lazarus M, Kobayashi T, Kaneko T, Narumiya S, Urade Y, Hayaishi O. Dominant Localization of Prostaglandin D Receptors on Arachnoid Trabecular Cells in Mouse Basal Forebrain and their Involvement in the Regulation of Non-Rapid Eye Movement Sleep. Proc Natl Acad Sci U S A. 2001; 98: 11674-9

Beuckmann CT, Lazarus M, Gerashchenko D, Mizoguchi A, Nomura S, Mohri I, Uesugi A, Kaneko T, Mizuno N, Hayaishi O, Urade Y. Cellular Localization of Lipocalin-type Prostaglandin D Synthase (β-Trace) in the Central Nervous System of the Adult Rat. J Comp Neurol 2000; 428: 62-78

Adam W, Lazarus M, Hoch U, Korb MN, Saha-Möller CR, Schreier P. Horseradish Peroxidase-Catalyzed Enantioselective Reduction of Racemic Hydroperoxy Homoallylic Alcohols: A Novel Enzymatic Method for the Preparation of Optically Active, Unsaturated Diols and Hydroperoxy Alcohols. J Org Chem 1998; 63: 6123-6127

Adam W, Lazarus M, Schmerder A, Humpf H-U, Saha-Möller CR, Schreier P. Synthesis of Optically Active α-Hydroxy Acids by Kinetic Resolution Through Lipase-Catalyzed Enantioselective Acetylation. Eur J Org Chem 1998: 2013-2018

Adam W, Boland W, Hartmann-Schreier J, Humpf H-U, Lazarus M, Saffert A, Saha-Möller CR, Schreier P. α-Hydroxylation of Carboxylic Acids with Molecular Oxygen Catalyzed by the α Oxidase of Peas (Pisum sativum): A Novel Biocatalytic Synthesis of Enantiomerically Pure (R)-2-Hydroxy Acids. J Am Chem Soc1998; 120: 11044-11048

Adam W, Lazarus M, Saha-Möller CR, Schreier P. Quantitative Transformation of Racemic 2-Hydroxy Acids into (R)-2-Hydroxy Acids by Enantioselective Oxidation with Glycolate Oxidase and Subsequent Reduction of 2-Keto Acids with D-Lactate Dehydrogenase. Tetrahedron Asymmetry 1998; 9: 351-355

Adam W, Lazarus M, Boss B, Humpf H-U, Saha-Möller CR, Schreier P. Enzymatic Resolution of Chiral 2-Hydroxy Carboxylic Acids by Enantioselective Oxidation with Molecular Oxygen Catalyzed by the Glycolate Oxidase from Spinach (Spinacia oleracea). J Org Chem 1997; 62: 7841-7843

Adam W, Lazarus M, Saha-Möller CR, Schreier P . Enantioselective a Hydroxylation of Carboxylic Acids with Molecular Oxygen Catalyzed by the αOxidation Enzyme System of Young Pea Leaves (Pisum sativum): A Substrate Selectivity Study. Tetrahedron Asymmetry 1996; 7: 2287-2292

Adam W, Hoch U, Lazarus M, Saha-Möller CR, Schreier P. Enzyme-Catalyzed Asymmetric Synthesis: Kinetic Resolution of Racemic Hydroperoxides by Enantioselective Reduction to Alcohols with Horseradish Peroxidase. J Am Chem Soc 1995; 117: 11898-11901

Ma W, Yuan P, Zhang H, Kong L, Lazarus M, Qu W, Wang Y, Huang Z. Adenosine and P1 receptors: key targets in the regulation of sleep, torpor, and hibernation. Front. Pharmacol. 14:1098976, doi: 10.3389/fphar.2023.1098976. 2023.

Yasugaki S, Hayashi Y, Lazarus M. NREM-REM sleep regulation. In: Encyclopedia of Sleep and Circadian Rhythms (Second Edition), Kushida CA (ed). Academic Press, doi: 10.1016/B978-0-12-822963-7.00229-2, pp. 128-136, 2023.

Lazarus M, Oishi Y, Landolt HP. Chapter 45 – Adenosinergic control of sleep. In: Principles and Practice of Sleep Medicine (Seventh Edition), eds. M. Kryger, T. Roth & W.C. Dement. Elsevier; 2022.

Korkutata M, Agrawal L, Lazarus M. Allosteric Modulation of Adenosine A2A Receptors as a New Therapeutic Avenue. Int J Mol Sci. 23(4):2101. doi: 10.3390/ijms23042101. 2022

Lazarus M, Hayashi Y, Honjoh S, Vogt KE, Eban-Rothschild A, Liu Q, Sakurai T. Editorial: The gating and maintenance of sleep and wake: New circuits and insights. Frontiers in Neuroscience, 14:773, 2020, doi: 10.3389/fnins.2020.00773.

Lazarus M. Dick durch Schlafmangel. Spektrum der Wissenschaft: Gehirn & Geist, 2020, 56-60 (German language edition of Scientific American)

Lazarus M, Oishi Y, Bjorness TE, Greene RW. Gating and the need for sleep: dissociable effects of adenosine A1 and A2A receptors. Frontiers in Neuroscience, 13:740, 2019.

Zhou X, Lazarus M. Adenosinergic Control of Sleep/Wake Behavior. In: Dringenberg H, editor. Handbook of Sleep Research. vol. 30, HBBN, UK: Academic Press, pp. 125-136, 2019. 

Fukusumi S, Oishi Y, Soya S, Cao L. Efforts of International Institute for Integrative Sleep Medicine to solve sleep problems. Bioscience & Industry 76(6):516-521, 2018

Oishi Y, Hayashi Y, Yanagisawa M. Sleep-regulatory mechanisms and behavioral abnormalities associated with its dysregulation. Experimental Medicine (JIKKEN IGAKU ZOUKAN) 36(12):81-87, 2018

Lazarus M. 睡眠不足と体重増加、肥満との関連, Journal of Health, Physical Education and Recreation [Japanese: 体育の科学], 68(11):805-809, 2018.

Lazarus M. 睡眠不足と体重増加、肥満との関連, Journal of Health, Physical Education and Recreation [Japanese: 体育の科学], 68(11):in press, 2018

Oishi Y, Lazarus M. Reward system and sleep/wake [Japanese: 報酬系と睡眠・覚醒], Journal of Clinical and Experimental Medicine [Japanese: 医学のあゆみ], 263:761-764, 2017.

Oishi Y, “Clifford B. Saper” Clinical Neurosciene 34(4):494, 2017

Oishi Y, Michael Lazarus. The control of sleep and wakefulness by mesolimbic dopamine systems. Neuroscience Research 118:66-73, 2017

Lazarus M, Chen JF, Huang ZL, Urade Y, Fredholm BB. Adenosine and sleep. Handbook of Experimental Pharmacology, doi:10.1007/164_2017_36, 2017.

Fuller PM, Yamanaka A, Lazarus M. How genetically engineered systems are helping to define, and in some cases redefine, the neurobiological basis of sleep and wake. Temperature, 2:406-417, 2015.

Lazarus M, Huang Z-L, Urade Y. Osamu Hayaishi—from the discovery of oxygenases in soil microorganisms to unraveling the enigma of sleep in mammals. Temperature, 2:303-307, 2015.

Lazarus M, Urade Y. Adenosinergic regulation of sleep-wake behavior in the basal ganglia. In: Morelli M, Simola N, Wardas J. The Adenosinergic System – A Non-Dopaminergic Target in Parkinson’s Disease New York: Springer; p. 309, 2015

Jackson AC, Liu C, Fukuda M, Lazarus M and Gautron L. Neuroanatomy and transgenic technologies. Frontiers in Neuroanatomy, 8:157; doi: 10.3389/fnana.2014.00157, 2014.

Lazarus M*, Chen J-F, Urade Y, Huang Z-L*. Role of the basal ganglia in the control of sleep and wakefulness. Current Opinion in Neurobiology, 23:780-785, doi: 10.1016/j.conb.2013.02.001, 2013. 

Urade Y, Lazarus M. Prostaglandin D2 in the regulation of sleep. In: Shaw PJ, Tafti M , Thorpy MJ, editors. The Genetic Basis of Sleep & Sleep Disorders. Cambridge, UK: Cambridge University Press; 2013; p. 73.

Lazarus M, Huang Z-L, Lu J, Urade Y, Chen J-F. How Do the Basal Ganglia Regulate Sleep-wake Behavior? Trends in Neurosciences, 35: 723-732; doi: 10.1016/j.tins.2012.07.001, 2012

Lazarus M, Saper CB, Fuller PM. Genetic Dissection of Neural Circuitry Regulating Behavioral State Using Conditional Transgenics. Sleep Biol Rhythms 2011; doi:10.1111/j.1479-8425.2010.00469.x

Lazarus M, Saper C. The differential role of prostaglandin E2 Receptors in the CNS Response to Systemic Immune Challenge. In: Ader R, editor. Psychoneuroimmunology. Boston, MA: Academic Press; 2006; pp. 319-336; doi:10.1016/B978-012088576-3/50020-4

Lazarus M. The Differential Role of Prostaglandin E2 Receptors EP3 and EP4 in Regulation of Fever. Mol Nutr Food Res 2006; 50: 451-455

Adam W, Lazarus M, Saha-Möller CR, Schreier P. Biocatalytic Synthesis of Optically Active α-Oxyfunctionalized Carbonyl Compounds. Acc Chem Res 1999; 32: 837-845.

Adam W, Lazarus M, Saha-Möller CR, Weichold O, Hoch U, Häring D, Schreier P. Biotransformations with Peroxidases. In: Scheper Th, editor. Advances in Biochemical Engineering Biotechnology. Heidelberg, Germany: Springer; 1998. pp. 73-108; doi: 10.1007/3-540-69791-8_4

Lazarus M, Adam W, Saha-Möller CR, Schreier P. Biotransformations with Oxidases and Peroxidases for the Synthesis of Optically Active Building Blocks. In: Ishimura Y, Nozaki M, Yamamoto S, Shimizu T, Narumiya S, Mitani F. International Congress Series: Oxygen And Life – Oxygenases, Oxidases and Lipid Mediators; November 26-29, 2000; Kyoto, Japan. Amsterdam, Netherlands: Elsevier; 2002. pp. 467-473

Adam W, Diaz MT, Fell RT, Groer P, Mock-Knoblauch C, Saha-Möller CR, Weichold O, Boss B, Hoch U, Humpf H-U, Lazarus M, Lukacs Z, Schreier P. Biocatalytic Synthesis of Optically Active Oxyfunctionalized Compounds. In: Werner H, Schreier P. Selective Reactions of Metal-Activated Molecules; September 17-19, 1997; Würzburg, Germany. Braunschweig, Germany: Vieweg Verlag; 1998. pp. 39-42